Avermectin Premix

Active Ingredients: Avermectin

Avermectin Premix is an antiparasitic drug used to treat internal and external parasites in poultry or pigs. This medication may be added to feed and used for the treatment and prevention of nematodes such as gastrointestinal roundworms, grubs, lungworms, sucking lice, and mange mites.

Avermectin is within the family of medicines called anthelmintics. It is derived from Streptomyces avermitilis's fermented products. Avermectin works by inhibiting the function of aspects of the nervous system within the parasite. This leads to its paralysis and then the death of the parasite.

This drug belongs to the group of macrocyclic lactones and is a chemical derivative of soil microorganisms from the genus Streptomyces. These drugs have a potent, broad antiparasitic spectrum at low dose levels. It is active against many immature nematodes and arthropods. It is effective against more than 300 species of endo- and ectoparasites in a wide range of hosts. A single therapeutic dose can persist in concentrations sufficient against new nematode infections for a prolonged treatment period.

This drug is well absorbed when administered orally. No matter the route of administration, macrocyclic lactones are well distributed throughout the body and concentrate in the adipose tissue. The distribution and the residence time of macrocyclic lactones can be influenced by the animal’s body condition. Effective levels are reached in the lungs, skin, and gastrointestinal system.

There is a complicated relationship between different parts of the body and how much of the drug is there. For instance, when certain medicines are mixed with food in the stomach, it can change how the body absorbs, uses, and gets rid of the drug. So, giving a drug like avermectin by mouth to animals might work differently depending on what and how much they eat. Also, if you stop giving them food before the treatment, it can make the drug work even better by changing how the body deals with it, making it more effective against parasites.

This is a antiparasitic drug that is used for treating parasitic infections. The drug is excreted in the feces and has a broad range of insecticidal activities. This drug can remain in the soil and has a half-life of 7 to 14 days. The remaining period depends on the environment. In the northern hemisphere, decomposition is slow (it is from 91-217 days).

A single dose of avermectin can persist in sufficient concentrations against susceptible nematode infections for prolonged periods. Prolonged efficacy leads to better treatment results. It can also protect the animals from reinfection by some nematodes and arthropods for several weeks.

It is important to note that Avermectin Premix is for veterinary purposes only.

This drug is also available in the form of injection and pour-on solution.

Avermectin Premix is manufactured and produced by AdvaCare Pharma, a pharmaceutical company specializing in global distribution. Our focus on quality has made AdvaCare a market leader in many countries.

AdvaCare Pharma is a reputable and leading manufacturer of Avermectin Premix. Our product range of 250+ veterinary medicines are customized and adapted to address the market requirements of our veterinary distributors. We provide unparalleled assistance throughout the entire journey - including support with documentation and product registration. By adhering to strict GMP standards, we ensure that the manufacturing of our Avermectin Premix and 30+ other veterinary premixes and oral powders are efficacious and of reliable quality.

What is Avermectin used for?

What animals can be treated with Avermectin Premix?

This drug is recommended for poultry and pigs.

How is Avermectin Premix used?

This product has been manufactured as powder, which is intended to be mixed into feed. The product should be used immediately when mixed with feed.

How can Avermectin Premix help in treating parasitic infections?

Avermectins are known as potential neurotoxins that target gamma-aminobutyric acid receptors (GABA) and the glutamate-gated chloride ion channels, which contribute to the neurotransmissions in parasites. GABA causes chloride ion channel opening and results in the influx of chloride ions. Avermectins are agonists of the chloride channels and lead to changed permeability of the channels and neurotransmission disturbances. This leads to neuronal membrane hyperpolarization, paralysis, and death of the parasite. Avermectins cannot cross the protective blood-brain barrier in animals, which makes them relatively safe for animals.

Can Avermectin Premix be used as a preventative drug?

Yes, many farmers use Avermectin Premix as a prevention for parasitic infection, but this is not the best choice. Extensive application of the drugs can lead to rapid selection and resistance, which can survive drug administration. Good hygiene measures must be provided in farms in order to save the animals from parasitic infections.

Is only Avermectin Premix enough for treating parasitic infections?

Avermectin is effective only against certain parasites, and its efficacy can depend. For some parasites, additional treatments might be needed. Rotation with antiparasitic drugs is also crucial in order to avoid drug resistance. The treatment choice depends on the veterinarian and the animal’s current health condition.

Which clinical signs can be addressed with Avermectin Premix?

Avermectin Premix can treat the signs of parasitic infections like losing body condition, coughing, loss of appetite, vomiting, and anemia.

Antiparasitic drugs in animals can indirectly protect human health and stop the spreading of some zoonotic infections. Zoonotic infections are spread through unclean water, food, pastures, and raw meat.

How should Avermectin Premix be stored?

This medication should be stored in a dark, dry location under 30°C.

What is the withdrawal period for Avermectin?

The withdrawal period is 35 days. Do not use this medicine for lactating dairy cows, as the withdrawal time is unknown.

How much Avermectin Premix should be given to poultry?

The usual dose is 2-10g per ton of feed. The duration of treatment is 3-5 days.

The veterinarian should determine the dose based on the animal’s species, weight, age, and current health condition.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Avermectin Premix.

Serious side effects may include: • allergic reaction (skin rash, fever, facial swelling, or difficulty breathing)

Massive usage of Avermectin can lead to drug resistance. It is associated with genetic mutations and extensive drug applications.

Giving animals avermectins can impact nature because when animals defecate, the drug comes out in the environment. Avermectins don't just affect parasites; they also harm non-parasitic creatures like dung beetles in the environment, which play a crucial role in recycling nutrients and breaking down organic matter. Extensive usage of these drugs, both in animals and humans, can lead to problems. The leftover drug in the environment may make parasites resistant, making it crucial to use avermectins carefully to protect nature from their harmful effects.

Nephrotoxicity, hepatotoxicity, neurotoxicity, and reproductive toxicity are the main side effects in animals.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Do NOT use Avermectin Premix for an animal that has a known allergy or hypersensitivity to any of the ingredients.

DO NOT use macrocyclic lactones for aquatic organisms. This drug is highly toxic for aquatic animals. It also has adverse effects on freshwater algae and the growth of plants.

This drug will have better effects if the animals are not well-fed before administration (but avoid starvation). The drug can have a longer exposure time and better treatment results.

Make sure to give a proper and correct dosage according to the recommended guidelines for the specific animal type. Veterinarians should provide guidance on dosage, frequency, and potential interactions with other medications.

Be aware of the withdrawal period. Follow the country’s regulations to prevent any potential residues.

Be cautious when treating pregnant females or lactating animals.

If the animals have a chronic problem with parasitic infections, use other drugs in order to avoid adverse effects. This will reduce the risk of drug resistance.

Keep the drug out of reach of children and animals.

Pig Parasitic Infections

This drug can help in treating parasitic infections like gastrointestinal nematodes, including Ascaris suum, Hyostrongylus rubidus, Oesophagostomum spp., Strongyloides ransomi, and Trichocephalus suis. It is also effective against pulmonary infections like Metastrongylus spp., as well as Stephanurus dentatus, Haematopinus suis, and Sarcoptes scabiei.

Poultry Parasitic Infections

Avermectin has proven to be effective in treating a variety of parasitic infections in poultry. It exhibits significant efficacy against most adult roundworm species, including common ones like Ascaridia galli (large roundworm), Heterakis gallinarum (cecal worm), Syngamus trachea (gapeworm), and Oxyspirura mansoni (manson eye worm). Additionally, it demonstrates variable effectiveness against Capillaria (threadworms) when administered at safe dosages.

In the cases of mite infestations, Avermectin is effective against several species. It has demonstrated efficacy against mites such as Cytodites nudus (airsac mites), Laminosioptes cisticola (fowl cyst mites), Knemidocoptes mutans (scaly leg mites), and Cnemidocoptes derooi. However, its effectiveness with Ornithonyssus spp (fowl mites) may vary, showing mixed results.