Toltrazuril Oral Solution (100ml bottle, 500ml bottle and 1L bottle)
Toltrazuril Oral Solution (1 bottle)
Toltrazuril Oral Solution (100ml bottle, 500ml bottle and 1L bottle)
Toltrazuril Oral Solution (1 bottle)
*Packaging color and/or animals may vary according to distribution region.

Toltrazuril Oral Solution

TotraCare™
Toltrazuril Oral Solution is an antiprotozoal drug indicated for coccidiosis. AdvaCare Pharma is a trusted manufacturer of veterinary oral solutions. Our veterinary range comprises more than 400 GMP and ISO-certified products distributed across the globe.

Dosage

Packaging

What is Toltrazuril?

Therapeutic Class:
Target Species:

Active Ingredients: Toltrazuril

Toltrazuril Oral Solution is an anticoccidial drug that is used to prevent or treat coccidiosis in animals such as chickens, piglets, turkeys, sheep, and cows. It also helps reduce coccidian shedding caused by E. bovis. or E. zuernii. Toltrazuril is sometimes used to treat isosporiasis and hepatozoonosis.

Toltrazuril is an antiprotozoal agent that is a derivative of triazinetrione. It works by causing damage at the cellular level of all stages of Eimeria (coccidia), including E. acervulina, brunetti, maxima, mitis, necatrix and tenella in poultry. It's effective against E. adenoides, galloparonis and meleagridis in turkeys. Toltrazuril also shows activity against schizonts and micro- and macrogametes.

This drug's mode of action involves disrupting cellular processes in all stages of the parasite's life cycle, including schizonts and gametes. It is considered a valuable choice for managing coccidiosis in poultry and livestock, contributing to improved animal health and reduced economic losses in the agriculture industry.

Note that Toltrazuril Oral Solution is for veterinary purposes only.

AdvaCare Pharma is a trusted global producer and exporter of Toltrazuril Oral Solution. This veterinary medication is manufactured in our GMP-certified facilities in China, India, and the USA.

Why are we a quality Toltrazuril manufacturer?

AdvaCare Pharma, an American company, is a quality manufacturer of Toltrazuril Oral Solution for veterinary use. We are committed to the manufacture and global distribution of over 250 GMP-certified veterinary medicines, including 70+ oral liquid formulations.

As a trusted Toltrazuril manufacturer, our approach to supply chain management is systematic and data-driven. We provide unparalleled support to our veterinary distributors, assisting with document and product registration, supply chain coordination and market share growth.

Uses

What is Toltrazuril used for?

It's used to treat parasitic infections caused by coccidia. It is sometimes used to treat roundworm infections or isosporiasis.

What animals can be treated with Toltrazuril Oral Solution?

It's recommended for poultry, piglets, cows, and sheep.

How is Toltrazuril Oral Solution used?

This medicine has been manufactured as a solution, which is intended to be diluted and administered orally. It is typically added to drinking water.

How does Toltrazuril Oral Solution work against coccidia and roundworms?

Toltrazuril disrupts the reproduction and development of coccidia and some roundworms, preventing their multiplication and ultimately leading to their death.

Can pregnant animals be treated with Toltrazuril Oral Solution?

Toltrazuril is generally considered safe for use in pregnant animals, but still consult with a veterinarian for specific guidance.

Can Toltrazuril Oral Solution be used in animals of all ages, including young animals and neonates?

Yes, including young animals and neonates, to prevent or treat coccidial infections. Dosing is based on body weight.

Is there a withdrawal period after treatment with Toltrazuril?

The withdrawal time is 48-63 days for meat and offal. Not authorised for use in animals producing milk for human consumption. The exact duration will depend on local regulations.

Can Toltrazuril Oral Solution be used as a preventive measure, or is it only for treating active coccidial infections?

The drug can be used for both. It is often administered preventively during periods of increased susceptibility or stress, such as weaning or transportation, to reduce the risk of coccidiosis outbreaks.

Is Toltrazuril Oral Solution available without a prescription or over-the-counter for animal use?

In many regions, this drug requires a prescription from a veterinarian.

Is there a risk of developing resistance to Toltrazuril in coccidia or roundworms over time?

Yes. Prolonged and indiscriminate use of this drug can lead to the emergence of resistant strains of these parasites. To mitigate resistance, follow proper dosing protocols, use this medication judiciously while implementing effective parasite management strategies.

Can Toltrazuril Oral Solution be used in conjunction with other dewormers or medications?

It is typically used as a standalone treatment and is not usually mixed with other dewormers or medications. Combining toltrazuril with other drugs should be done under the guidance of a veterinarian, as drug interactions can occur.

Are there any known contraindications or specific conditions under which Toltrazuril should not be used?

There are no known contraindications for toltrazuril in animals. Consult a veterinarian before using this drug in animals with specific medical conditions or those on other medications to ensure compatibility and safety.

Can Toltrazuril Oral Solution be used in backyard or small-scale poultry farming, or is it primarily for commercial poultry operations?

It can be used in both commercial and small-scale poultry farming, as well as backyard poultry flocks, of course, with proper veterinary guidance.

Can Toltrazuril Oral Solution be used to treat coccidiosis or roundworms in wild or exotic animals?

Toltrazuril is primarily intended for use in domesticated livestock and poultry. Its use in wild or exotic animals should be done under the guidance of a veterinarian experienced in exotic animal care.

Is Toltrazuril Oral Solution available in different concentrations or formulations?

Yes. It is available in two formulations: 2.5% (25mg/ml) and 5% (50mg/ml).

Can Toltrazuril Oral Solution be purchased without a prescription?

Its availability without a prescription can vary by region and local regulations. Verify local laws and regulations regarding the acquisition and administration of Toltrazuril to ensure compliance and the safe use of this drug.

Can Toltrazuril Oral Solution be used in animals with compromised immune systems?

Yes, it can be used in animals with compromised immune systems, but the dosage and treatment plan should be determined by a veterinarian to account for the specific health needs.

Are there any known drug interactions between Toltrazuril Oral Solution used in livestock and poultry?

There are generally no known drug interactions between Toltrazuril Oral Solution and other products used concurrently. It is considered a relatively safe and well-tolerated when used as directed. But always exercise caution when combining toltrazuril with other medications, especially those that may affect the liver or kidneys, as it could potentially lead to increased toxicity.

How should Toltrazuril Oral Solution be stored?

This medication should be stored in a dark, dry location under 30°C. Keep the bottle tightly sealed and out of reach of children and pets when not in use.

Dosage

How much Toltrazuril Oral Solution should be given to poultry?

The usual dose is 7mg/kg. The duration of treatment is 2 days. Treatment can be repeated after 5 days if necessary.

How much Toltrazuril Oral Solution should be given to piglets?

Each pig to be treated on day 3-5 of life with a single oral dose of 20mg/kg body weight corresponding to 0.4 ml oral suspension per kg body weight.

How much Toltrazuril Oral Solution should be given to sheep?

The usual dose is 20mg/kg (about 0.4ml/kg). The duration of treatment is 2 days.

How much Toltrazuril Oral Solution should be given to cattle?

The recommended dosage for cattle typically ranges from 7mg/kg to 15mg/kg of body weight. For the treatment of a group of animals of the same breed and same or similar age the dosing should be done according to the heaviest animal of this group.

What should be done in case of accidental overdose with Toltrazuril Oral Solution?

If an overdose is suspected, contact a veterinarian immediately. A professional can assess the situation, provide guidance on any necessary treatments or interventions, and monitor your animal's health to minimize any potential risks.

What should be done if a dose of Toltrazuril Oral Solution is missed?

Administer it as soon as remembered, but if it's already close to the time for the next scheduled dose, skip the missed dose and continue with the regular dosing regimen. Do not double the dose to make up for the missed one.

Can Toltrazuril Oral Solution be administered simultaneously to an entire group or flock of animals, or should each animal be treated individually?

Toltrazuril Oral Solution can be administered to a group or flock of animals simultaneously, making it suitable for mass treatments. Ensure accurate dosing for each animal based on their individual weight to avoid under- or overdosing.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

Side Effects

As with all pharmaceuticals, some unwanted effects can occur from the use of Toltrazuril Oral Solution.

Some adverse effects may include but are not limited to: • gastrointestinal effects (upset stomach, diarrhea)

Serious side effects may include:

  • allergy or hypersensitivity reactions
  • growth inhibition and polyneuritis in poultry (high doses)

Toltrazuril is generally well-tolerated in animals when used as directed. Severe adverse reactions are rare but should be reported to a veterinarian if observed.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Precautions

Do NOT use Toltrazuril Oral Solution for an animal that:

  • has a known allergy or hypersensitivity to any of the ingredients.
  • is hypersensitive to similar drugs, such as ponazuril.
  • produces eggs for human consumption.

Gloves should be worn when handling this medication. Exposure to this drug can cause adverse effects in humans. Do not ingest this product, and avoid contact with skin and eyes.

Prolonged usage of any antiprotozoal drug within the same family may result in parasite resistance.

What are the most common animals Toltrazuril Oral Solution is used for?

Toltrazuril Oral Solution is typically used in following types of animals:

  • Cattle: Toltrazuril Oral Solution is commonly used in cattle, particularly cows, to manage coccidiosis, a parasitic disease caused by various species of protozoa. Coccidiosis can affect the intestinal tract and lead to diarrhea, weight loss, and reduced growth in cows. Toltrazuril is administered orally to treat and prevent coccidiosis to help control the spread of the parasite.
  • Piglets: For the prevention of clinical signs of coccidiosis in neonatal piglets (3 – 5 days old) on farms with a confirmed history of coccidiosis caused by Cystoisospora suis.
  • Sheep: This drug is also used in sheep to prevent and treat coccidiosis. Coccidiosis can be a significant concern in sheep, especially in young lambs, and it can lead to diarrhea, dehydration, and even death if left untreated.
  • Poultry: In poultry, including chickens and turkeys, Toltrazuril is employed to also combat coccidiosis. Coccidiosis can lead to reduced feed conversion, growth retardation, and increased mortality in poultry. The drug is administered to help control coccidial infections, reduce oocyst shedding, and promote healthier and more productive flocks.
*Regulatory compliance may vary according to production standard, import requirements and/or manufacturing origin.
Sandra Tashkovska Profile
Medically reviewed by Sandra Tashkovska, DVM
October 14, 2024

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