Sulfadiazine Sodium + Trimethoprim Injection

Active Ingredients: Sulfadiazine Sodium, Trimethoprim

Sulfadiazine Sodium + Trimethoprim Injection is an antibiotic/antimicrobial combination drug used to treat infections in cats, dogs, horses, cows, and pigs. This medicine is indicated for the treatment of certain gastrointestinal, respiratory, and urinary tract infections caused by susceptible microorganisms.

This injectable solution contains the active ingredients sulfadiazine and trimethoprim. Sulfadiazine is classified as a sulfonamide antibiotic. It displays action against most gram-positive and many gram-negative bacteria. It works by inhibiting folic acid synthesis within the bacteria. Trimethoprim is classified as an antibiotic and folate synthesis inhibitor.

This drug is well absorbed after administration and reaches high therapeutic plasma concentrations. It is well distributed into body tissues and fluid and penetrates the respiratory tract, gastrointestinal tissues, urogenital tract, and synovial fluids. Trimethoprim binds to proteins (40-70%), and sulfadiazine has a lower binding affinity (20-30%). This drug is metabolized in the liver and undergoes acetylation and conjugation (sulfadiazine), and trimethoprim is metabolized into several inactive metabolites.

This antibiotic is excreted via the kidneys and the half-life varies (between 5 and 12 hours).

Sulfadiazine inhibits the bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). This blocks the production of folic acid which is needed for bacterial growth and replication. Trimethoprim inhibits the bacterial dihydrofolate reductase which is needed for the conversion of dihydrofolic acid to tetrahydrofolic acid.

The combination shows a broad range of activity against gram-positive and gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus, and Streptococcus.

It is important to note that Sulfadiazine + Trimethoprim Injection is for veterinary purposes only.

AdvaCare Pharma is a trusted global exporter of Sulfadiazine + Trimethoprim Injections. This medicine is produced in our GMP-certified facilities in China, India, and the USA. These facilities are routinely audited to ensure they comply with health, safety, and environmental standards.

Sulfadiazine + Trimethoprim Injection is manufactured and globally distributed by AdvaCare Pharma, a leading manufacturer of veterinary injections in the pharmaceutical industry. We have been committed to distributing high-quality, GMP-certified veterinary medications for the global market over the past 20 years. As a top Sulfadiazine + Trimethoprim manufacturer, we ensure that all of our 100+ veterinary injections surpass our distributors' requirements by conducting routine internal and third-party facility audits.

What is Sulfadiazine Sodium + Trimethoprim used for?

What animals can be treated with Sulfadiazine Sodium + Trimethoprim Injection?

It is recommended for horses, cows, and pigs. It's also used to treat companion animals like dogs and cats.

How is a Sulfadiazine Sodium + Trimethoprim Injection used?

This medication has been manufactured as a liquid, which is packaged in a vial. It is intended to be administered by intramuscular (IM), intravenous (IV), and subcutaneous (SC) injection. Sulfadiazine Sodium + Trimethoprim Injection is intended for veterinary use only.

In cattle and pigs, it should be administered intramuscularly or by slow intravenous injection. In horses, it should be administered only by slow intravenous injection. In companion animals, it should be only administered by a subcutaneous injection.

Why is Sulfadiazine Sodium + Trimethoprim Injection used in cattle and pigs?

This antimicrobial drug is used for treating various bacterial infections that are susceptible to the drug.

Why is Sulfadiazine Sodium + Trimethoprim Injection used in horses?

This antibiotic can help relieve the signs of pneumonia, pleuropneumonia, and bacterial bronchitis in horses, as well as other bacterial infections that affect other tracts. Studies show that trimethoprim-sulfadiazine can help in the treatment process of Streptococcus equi subsp. zooepidemicus. This study included 119 horses, and 58% of them had a positive clinical response.

Is only this antibiotic enough to treat a respiratory infection?

It depends on the severity of the health issue. In some mild cases, only this antibiotic can improve the overall health status of the animal, but very often, other drugs and supplements might be included.

Can Sulfadiazine Sodium + Trimethoprim Injection be used for pregnant animals?

It should be used only if the benefits outweigh the risks. The veterinarian should examine the animal before adding any antibiotic or other drug to a pregnant or lactating animal.

Can Sulfadiazine Sodium + Trimethoprim Injection interact with other drugs?

This antibiotic might interact with amantadine, antacids, cyclosporines, or potassium supplements. Owners should inform the veterinarians about any drugs the animal is taking at the moment.

How should Sulfadiazine Sodium + Trimethoprim Injection be stored?

This medication should be stored in a dark, dry location under 30°C. The vial should be sealed tightly.

What is the withdrawal period for Sulfadiazine Sodium + Trimethoprim?

The withdrawal time is 7-15 days for meat.

How much Sulfadiazine Sodium + Trimethoprim Injection should be given to livestock?

The usual dose is 15mg/kg, given once or twice per day. The duration of treatment should be 2-3 consecutive days. It should be administered intramuscularly or by slow intravenous injection.

How much Sulfadiazine Sodium + Trimethoprim Injection should be given to horses?

The usual dose is 15mg/kg, given once or twice per day. It should be administered only by slow intravenous injection.

How much Sulfadiazine Sodium + Trimethoprim Injection should be given to companion animals (dogs and cats)?

The usual dose is 1 ml per 8kg of body weight, given once or twice per day. It should be administered only by a subcutaneous injection.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Sulfadiazine Sodium + Trimethoprim Injection.

Some common side effects may include but are not limited to: • temporary swelling near injection site

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Treatment with this drug should be administered with caution for an animal that is dehydrated.

If the owners notice any side effects, they should report it immediately to a veterinary professional.

The dosage should be carefully selected in animals with impaired liver or kidney function. Pregnant and lactating animals should be treated only if the benefits outweigh the risks.

Owners should inform the veterinarians about any drugs or supplements that the animal is taking at the moment. They should also be aware of the animal's previous medical history.

Companion Animals (Cats and Dogs) Bacterial Infections

Dogs and cats can be treated with this antibiotic when the bacteria are susceptible to it. It is used for treating respiratory tract infections like bronchitis and pneumonia. It can reduce the bacterial load and alleviate the symptoms. Sulfadiazine Sodium + Trimethoprim can also help in the treatment process of cystitis, pyelonephritis, and other urinary tract infections that are caused by bacteria susceptible to the antibiotic.

This antibiotic also helps in treating skin and soft tissue infections like abscesses, cellulitis, and wound infections, as well as digestive tract infections like enteritis and diarrhea. This drug can also help in the treatment process of metritis and prostatitis.

Horse Bacterial Infections

In horses, this antibiotic can help relieve the signs of pneumonia, pleuropneumonia, and bacterial bronchitis. It is also effective in treating urinary tract infections like bacterial cystitis and pyelonephritis. This antimicrobial drug can help in the treatment process of septic arthritis and osteomyelitis.

Cattle Bacterial Infections

This injection can improve the overall health status of cattle that suffer from bacterial infections. It can also be used for treating Bovine respiratory disease complex (BRDC), pneumonia, and shipping fever. It can help in the treatment process of bacterial infection of the mammary gland and can improve milk production and quality. Gastrointestinal and urinary tract infections can also be managed with this antibiotic. Infectious pododermatitis (foot rot) in cattle that is caused by susceptible bacteria can also be treated with this antibiotic.

Pig Bacterial Infections

In pigs, this antibiotic can be used for treating Swine Respiratory Disease complex (SRD) and atrophic rhinitis. It can alleviate the symptoms and improve the breathing process. It also helps in cases of gastrointestinal bacterial infections like colibacillosis and salmonellosis. Urogenital infections like cystitis, pyelonephritis, and other urinary tract infections can also be managed. Piglets affected with bacterial arthritis and joint infections can also be treated with this injection.

The treatment process should be started only if the antibiogram results show that the bacteria present are susceptible to this antibiotic. Veterinarians should decide whether the drug is appropriate for the animal’s current health condition.