Pefloxacin Tablets

Active Ingredients: Pefloxacin

Pefloxacin Tablets are a broad-spectrum antibiotic used to treat bacterial infections in birds and poultry. It is indicated for respiratory infections, including Mycoplasmosis, chronic respiratory disease (CRD) complex, mixed bacterial infections, and secondary bacterial infections due to viral diseases.

Pefloxacin is a quinolone antibiotic that is active against both gram-positive and gram-negative bacteria. It works by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV. These enzymes are essential for DNA synthesis within the bacteria.

This synthetic antimicrobial agent, derived from Quinolone carboxylic acid, is employed to manage intestinal and respiratory infections in production animals. Quinolones, known for their amphoteric properties, generally exhibit limited water solubility within the pH range of 6–8. Although the impact on therapeutic efficacy is not fully understood, their functioning as weak bases renders them less effective in acidic urine pH compared to non acidic conditions. In concentrated acidic urine, certain quinolones may form needle-shaped crystals. Quinolones intended for oral or parenteral administration typically include freely soluble salts in stable aqueous solutions, with oral administration being the most common method. The drug's bioavailability exceeds 80%, and its efficacy can be influenced if administered after the animals have consumed food.

Concerning distribution, the drug effectively permeates all tissues due to its high lipid solubility, with tissue concentrations consistently surpassing plasma concentrations. Elevated concentrations are also observed in elimination-related organs such as the kidneys, liver, and bile. Additionally, the drug is present in prostatic fluid, bone, ocular fluid, endometrium, and cerebrospinal fluid. Notably, quinolones can traverse the placental barrier.

Elimination of the drug occurs either unchanged or partially metabolized, primarily through renal excretion via glomerular or tubular secretion. Urinary concentrations remain high 24 hours after the last administration. Biliary excretion is common for pefloxacin.

The drug's mechanism of action involves inhibiting DNA gyrase, which hinders DNA supercoiling. It's essential to recognize that this medication operates in a concentration-dependent manner, and a once-per-day treatment regimen is typically sufficient.

Pefloxacin displays bactericidal activity against Staphylococcus, Clostridium Streptococcus, Corynebacterium, E. coli, Salmonella, Shigella, Pasteurella, Pseudomonas, Klebsiella, Haemophilia, and Mycoplasma.

AdvaCare Pharma is a trusted global exporter of Pefloxacin Tablets. We strive to offer the highest quality products to distributors and veterinary professionals. Our reliable, cost-effective livestock medications are manufactured under GMP guidelines.

Pefloxacin Tablets, manufactured and globally supplied by AdvaCare Pharma, are one of our 250+ veterinary medicines. From supply chain coordination to product registration support, our professional teams of specialists and experts provide our veterinary distributors unparalleled support. As a trusted Pefloxacin manufacturer, veterinarians and farmers alike rely on our high-quality veterinary tablets manufactured according to GMP standards.

What is Pefloxacin used for?

What animals can be treated with Pefloxacin Tablets?

This medicine is recommended for poultry and ornamental birds.

How are Pefloxacin Tablets used?

This medicine has been manufactured as a tablet, which is intended to be given orally to an animal. The tablets can be mixed with feed or water.

How can Pefloxacin Tablets help in the treatment of CRD Complex?

The Chronic Respiratory Disease (CRD) Complex is very common in poultry and birds. The cause is Mycoplasma gallisepticum and it occurs when the animals are stressed. It causes major damage to the bird’s respiratory system. This drug can help since the spreading is very fast via eggs, airborne transmission, and indirect or mechanical routes. Pefloxacin can reduce the signs of sniffling, coughing, sneezing, and difficulty breathing.

Are Pefloxacin Tablets enough for treating CRD Complex?

This antibiotic can address the cause of the disease - Mycoplasma gallisepticum, but sometimes veterinarians prescribe additional supplements to help in managing the disease. The disease can be prevented by vaccination. Isolation is also needed when new birds arrive at big farms. All-in, all-out systems can help in preventing the disease. Proper nutrition and flock dynamics are also needed. Farmers also need to be careful to provide proper hygiene practices. When administering this antibiotic, make sure to maintain normal hygiene. Additional secondary infections might affect the animals. This includes Escherichia coli, which can complicate the organism’s pathogenicity that results in air sacculitis and septicemia. If not treated properly, this can result in high morbidity and mortality. Veterinarians should perform antibiogram testing in order to determine the best antimicrobial drug.

How can Pefloxacin Tablets help in the treatment of Infectious Coryza?

This disease occurs only in chickens, especially in pullets, laying hens, and broilers. It is caused by Avibacterium paragallinarum. Pefloxacin is effective against this gram-negative bacteria. The drug can address the nasal discharge and facial swelling of animals. It can reduce the swelling around the infraorbital sinuses. Treating the disease can lead to normal egg production and quality. Early antibiotic treatment can help and lead to fast recovery. Chickens can return to their normal physical activity after the treatment.

This drug can be given with other drugs and supplements depending on the current health status. To prevent the disease, many biosecurity measures and vaccinations are needed.

How can Pefloxacin Tablets help in the treatment of coli-septicemia?

This is one of the most common diseases in farmed poultry and can be addressed with this antibiotic. It is a disease of the upper respiratory tract, and it is associated with Gumboro Disease and Haemorrhagic Enteritis. It is caused by E. coli, and the mortality is up to 20% if not managed on time with antibiotics.

This antibiotic is effective and can treat the signs of coughing, sneezing, snicking, dejection, reduced appetite, poor growth, and omphalitis. To prevent the disease and additional infection, good hygiene is crucial. Good hygiene is especially needed in cases of hatching eggs and housing practices. Vaccination can also prevent the disease.

How can Pefloxacin Tablets help in the treatment of secondary bacterial infections due to viral illnesses?

The antibiotic choice depends on the animal’s current condition and the veterinarian’s choice.

How should Pefloxacin Tablets be stored?

This medication should be stored in a dark, dry location under 30°C. Keep the tablets in the blister pack when not in use.

Is there a withdrawal period after treatment with Pefloxacin?

The withdrawal period is 8-10 days. The exact duration will depend on local regulations.

How much Pefloxacin should be given to poultry?

The usual dose is 50mg per kg of body weight. The duration of treatment is 3-7 days.

The dosage depends on the animal’s species, weight, age, and other individual characteristics. It also depends on the animal's current health condition.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Pefloxacin Tablets.

If you notice gastrointestinal changes like diarrhea, vomiting, or lack of appetite, contact a veterinarian as soon as possible.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

The effectiveness of this drug in animals can be diminished by the presence of food. The bioavailability may also be reduced through chelation when administered concurrently with antacids containing magnesium and calcium.

Lower doses are recommended for animals with kidney failure, as the primary elimination route for the drug is through urine.

Wearing gloves is advisable when handling this product, as it can cause irritation to the eyes and skin. In case of contact with eyes or skin, immediate washing is recommended.

It is essential to keep this product out of reach of both children and animals.

Poultry Bacterial Infections

Pefloxacin is utilized in the treatment of severe bacterial respiratory and gastrointestinal infections in poultry. It plays a role in managing Mycoplasma infections caused by susceptible bacteria in the respiratory tract. Additionally, Pefloxacin can effectively address Salmonella, Staphylococcal infections, and mixed bacterial infections. This antibiotic has demonstrated effectiveness against various enteric infections in poultry. Respiratory infections can be effectively treated with this antibiotic since it can reduce clinical signs of coughing, sneezing, nasal discharge, and difficulty breathing. It is also a good choice in cases of viral infections since it can address secondary bacterial infections in poultry and birds.