Water for Injection

Active Ingredients: Sterile Water

Sterile Water for Injection is used as a drug diluent in the aseptic preparation of parenteral solutions. It contains sterile, nonpyrogenic, distilled water in a single-dose container. Sterile Water should only be used as a fluid replacement after being appropriately prepared with additives or suitable medications.

Water is a vital component of all bodily tissues, constituting around 70% of total body weight. The typical daily requirement for the average adult ranges from two to three liters, with approximately 1.0 to 1.5 liters accounting for insensible water loss through perspiration and urine production.

Regulatory mechanisms play a crucial role in maintaining water balance. The distribution of water within the body relies largely on the concentration of electrolytes in various compartments, and sodium (Na+) plays a pivotal role in preserving physiological equilibrium.

Sterile Water for Injection is employed solely as a pharmaceutical aid to dilute or dissolve drugs for parenteral injection; the small volume it provides is unlikely to have a significant impact on fluid balance, except in some cases, including neonates or very small infants.

AdvaCare Pharma is a trusted global exporter of Water for Injection. This medication is manufactured in our GMP-certified facilities in China, India, and the USA. Our production facilities are regularly inspected to ensure they comply with WHO's standards, rules, and regulations.

AdvaCare Pharma, a US-owned pharmaceutical company, is a manufacturer of Water for Injection with GMP-compliant manufacturing facilities located worldwide. We conduct frequent GMP, third-party and internal facility inspections to ensure that our manufactured injectable treatments exceed the stringent requirements of importing countries and our distributors.

As a renown Water for Injection manufacturer and global supplier of 120+ pharmaceutical injection products, our global reach extends to over 65 markets ensuring that pharmaceutical distributors, hospitals, pharmacies, NGOs and government institutions receive the quality-assured treatments they need.

What is Sterile Water used for?

It is used to dilute drugs for parenteral administration. The Sterile Water is used for a parenteral preparation, and it is indicated for diluting or dissolving drugs. These drugs can be further used for intravenous, intramuscular, or subcutaneous administration. The dilution should be made based on the instructions on the drugs.

How is Sterile Water for Injection used?

This water has been produced to be without significant contaminations. It is produced as a single dose, which is to be mixed with appropriate drugs and delivered parenterally.

What dose should be given?

Following preparation with the prescribed additive, the dose is usually dependent upon the medical condition, age, weight, and clinical condition.

Refer to a doctor or pharmacist for guidelines on the exact dosage.

Can Sterile Water for Injection be used in pregnant women?

There are no studies that confirm the safety of the Sterile Water for injection. It is unknown if sterile water-containing additives cause fetal harm in pregnant women or can affect the reproduction capacity. It should be given to pregnant women only when clearly needed.

Can Sterile Water for Injection be used in the pediatric population?

The safety and effectiveness of Sterile Water for Injection is not well-established in pediatric patients. In neonates or small infants, the volume of the fluid may affect the fluid or electrolyte balance. It should be given to pediatric patients only when clearly needed.

Are there any known drug interactions?

Some drugs for injections might be not appropriate for mixing with Sterile Water or when combined in the same vehicle containing benzyl alcohol. Before combing certain medications, consult with a pharmacist.

Are there any significant side effects that might occur due to Sterile Water for Injection?

The most common reactions that might occur due to this solution are febrile reactions. On the site of administration, there is a chance for local tenderness, abscess, tissue necrosis, or infections. Venous thrombosis or phlebitis are also possible side effects on the injection site.

If any adverse effects occur, the physicians should stop the administration and detect the reason for it. They should evaluate the patients and take appropriate countermeasures. When possible, the remaining solution should be retrieved and saved for an examination.

Other warnings

When mixing Sterile Water for Injection with certain drugs, aseptic techniques must be followed. The diluting or dissolving drugs, the dilution should be mixed thoroughly and used promptly.

Reconstituted solutions of drugs for injections should not be stored unless directed otherwise by the manufacturer of the drugs.

The solution should not be used if it is cloudy or if the seal is not intact. Single-dose containers should not be reused. Unused portions should be discarded.

As with all pharmaceuticals, some unwanted effects can occur from the use of Water for Injection.

Common side effects include, but may not be limited to: • redness, swelling, or tenderness at the injection site

For a comprehensive understanding of all potential side effects, consult a medical professional.

If any symptoms persist or worsen, or you notice any other symptoms, please call your doctor.

Do NOT use Water for Injection if the osmolar concentration of additives results in an approximate isotonic admixture.

The drugs should be diluted or dissolved according to the instructions written on the drug. The reconstituted drugs (diluted or dissolved) must be checked for clarity. It should be checked for unexpected precipitation or discoloration before the administration occurs.

There is no data that confirms if Sterile Water for injection is safe for pregnant women, but patients should inform their doctors if they are pregnant, planning to become pregnant, or breastfeeding.

Patients should inform their doctors about any drugs they are taking.

This medication may not be suitable for people with certain conditions, so it is important to consult with a doctor if you have any health conditions.

Evidence reviews for sterile water injections

This study discusses the effectiveness of sterile water injections for pain relief during labor.

Water for injection is a cheap and relatively easy method of pain relief and one that could be widely available. Eleven studies were included in this review.

Sterile water injections at doses of 0.4ml and 2ml demonstrated significant benefits in alleviating general labor and back pains, particularly between 10 and 180 minutes post-injection. In comparison with saline injections, sterile water injections were more effective in reducing back pain during labor, particularly at the 0.4ml dose and within 10 to 120 minutes post-injection.

The conclusion of this study is that sterile water injections were generally found to provide benefits in managing general labor pain, back pain during labor, and overall satisfaction.

Sterile water injections for childbirth pain: An evidenced based guide to practice

This study discusses sterile water injections for managing low back pain in pregnant women. Almost 30% of women in labor have lower back pain and the main goal of this study is to provide an evidence guide for the clinical use of sterile water injections in lowering back pain in pregnant women.

This study included relevant publications from different scientific databases and a total of 12 studies were included. This paper gives recommendations about the clinical use of sterile water in terms of location of administration, injection techniques, number of injections, and the amount of sterile water. It also discusses the side effects.

The results revealed that different injection techniques provide good relieving lower back pain in pregnant women. The subcutaneous injection is more recommended than the intracutaneous because it is less painful.

The conclusion of this study is that four injections of sterile water can reduce lower back pain in women and different injection techniques can lead to pain relief. No side effects were observed in the mothers or indirectly in their fetuses from the use of sterile water injections.